Molecular Formula | C24H26ClFN4O |
Molar Mass | 440.94 |
Density | 1.36 |
Melting Point | 95-100°C |
Boling Point | 592.1±50.0 °C(Predicted) |
Appearance | Form solid, color off-white |
pKa | 14.53±0.20(Predicted) |
Storage Condition | Sealed in dry,2-8°C |
Physical and Chemical Properties | The chemical properties are crystallized from acetone with a melting point of 154~155 ℃; Or crystallized from isopropanol-ethyl acetate with a melting point of 166 ℃. |
Use | The use is 5HT2-antagonist. For the treatment of schizophrenia. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 3 |
RTECS | NJ0621100 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.268 ml | 11.339 ml | 22.679 ml |
5 mM | 0.454 ml | 2.268 ml | 4.536 ml |
10 mM | 0.227 ml | 1.134 ml | 2.268 ml |
5 mM | 0.045 ml | 0.227 ml | 0.454 ml |
Solubility | DMSO: >10mg/mL |
biological activity
Sertindole are 5-HT2A,5-HT2C,D2 and αl receptor antagonists.
Target
5-HT 2A Receptor
5-HT 2C Receptor
Production method
After the Grignard reaction between the compound (I) and the compound (II), the product (III) is hydrolyzed to obtain the product.